【適合對象】相關產業第一線工作人員或主管、需具製程相關知能之從業人員、有意投入相關領域者。
【課程規劃專家】連凌霄 副總經理(台灣神隆股份有限公司生產製造中心)
【上課時間】2020/12/5~ 2021/ 1/16 (異動) ，共6週，
       每週六9:30-12:30 / 13:30-16:30
【總時數】36小時  
【線上報名】我要報名

【上課地點】台北市大安區復興南路一段390號11樓(大安捷運站斜對面)
*復興南路與信義路口,近師大附中及大安高工
【課程簡介】
1. Train R&D chemists and engineers in the most efficient methods for developing cheap, robust processes for the manufacture of fine organic chemicals in the minimum amount of time. And educate chemists in the principles of scale-up and development, in basic engineering concepts and in techniques for the optimisation of processes.
2. Teach the practical aspects of designing a scalable fine-chemical batch process and successfully implementing it at the kilo-lab and pilot plant scale, through an examination of the effects of unit operation theory, large-scale operating methods and equipment limitations on process safety, operability, yield, selectivity and product quality.
 
【課程大綱】(預排)
 

12/05	Introduction      The purpose of chemical development      The approaches to process development Chemical Development & Optimization      Selecting the best route for scale-up      Choice of raw material, reagent, solvents, etc.      Optimizing chemical reaction      Work-up, crystallization & product isolation	郭隆皇博士 松瑞製藥股份有限公司 製程研發部副總經理
12/5 下午	Analytical Issues      In process control      Quality control and specification setting      Regulatory guidelines Quality by Design & Control Strategy Case study
12/12 上午	Scale-Up      Overview of scale-up issues      Making process robust & minimizing scale-up difficulties Chemical Engineering Aspects      Mass transfer & mixing      Heat transfer & kinetics	連凌霄 台灣神隆股份有限公司 生產製造中心 副總經理
12/12 下午	Thermal Hazard Testing & Runaway Reactions      Process safety consideration      Equipment & screening approach Process Scale-Up & Assessment      Introduction      Drivers for development & risk assessment      On unit operations
12/19 上午	Reaction      Scale-up of a chemical reaction      Heat transfer & agitation in batch reactors      Exploiting process understanding in scale-up Reaction Quench Color & metal removal	沈育維 台灣神隆股份有限公司 製程技術部 處長
12/19 下午	Extraction      Liquid-liquid extraction      Scale-up of extraction processes Distillation & Stripping      Vapor-liquid equilibrium diagram      Scale-up of distillation process Case study
12/26 上午	Crystallization & Precipitation      Basic principle      Controlling supersaturation      Batch crystallization scale-up and issues Case study	連凌霄 台灣神隆股份有限公司 生產製造中心 副總經理
12/26 下午	Product Isolation & Drying      Background & principles      Filtration & drying equipment      Scale-up & trouble-shooting Milling Operations      Type of milling & milling equipment      Milling operations & scale-up
1/9上午	New Technologies - Continuous Flow Process      Introduction of continuous flow process      The fundamental mechanism of mass & heat transfer in flow reactors      Process R&D and scale-up of continuous flow process      The shift from batch to flow process development      Process analytical technology (PAT)	楊立勔博士 瑞林科技顧問公司副總經理     江佩珍 台灣康寧研發中心資深研究員
1/ 9下午	Peptide Process Development      Introduction of peptide products      Synthetic strategy      Peptide process development - synthesis, purification, lyophilization      Analytics	莊宏偉 台灣神隆股份有限公司 製程研發中心計畫主任
1/ 16 上午	Column chromatography      Design of chromatographic process      Scale-up of chromatographic process      Operational aspects and economics Lyophilization      Basic concept & process      Lyo cycle development      Scale-up of lyophilization process & process control	沈育維 台灣神隆股份有限公司 製程技術部處長
1/16 下午	Kilo Lab & Pilot Plant Manufacturing      Facility design      Equipment      Operating principles & regulatory drivers  Summary

 
【上課時間】2020/12/5~ 2021/ 1/16 (異動) ，共6週，每週六9:30-12:30 / 13:30-16:30
 元旦連續假期停課一次
【總時數】36小時
【上課地點】台北市大安區復興南路一段390號11樓(大安捷運站斜對面)
復興南路與信義路口
【課程費用】協會團體會員NT$21,600；非團體會員NT$23,400。

• 10/30前完成繳費 可享 早鳥優惠價每人NT$ 19,800
• 同公司2人以上同行,每人只要NT$ 19,800
• 原料藥班之結訓學員 (舊生).報名今年度課程,每人只要NT$ 12,000 (限額4人)

【線上報名】我要報名
【諮詢專線】02-77003883 分機11或 分機12 歡迎來電
(注意事項:以上課綱及開課日期/授課師資/場地..等;本協會保有異動權，如有變動將會提前通知)